. (Am J Orthod Dentofacial Orthop 2016;149:692-8)
Influence of TNF-a-308 G/A gene polymorphism on temporomandibular disorder
Tumor necrosis factor alpha (TNF-a) levels are significantly upregulated in the synovial fluid of patients with temporomandibular joint disorder (TMD). The TNF-a influences pain generation and maintenance. Therefore, the aim of this study was to investigate the influence of single nucleotide polymorphism TNFA-308 (rs1800629) on TMD risk and on the pressure pain threshold.