J Clin Periodontol 2017; 44: 67–82
Aim: To analyse the regenerative potential of leucocyte- and platelet-rich fibrin (L-PRF) during periodontal surgery. Materials and Methods: An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta-analysis was performed. Results: Twenty-four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra-bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta-analysis was performed in all the subgroups. Significant PD reduction (1.1 0.5 mm, p < 0.001), CAL gain (1.2 0.6 mm, p < 0.001) and bone fill (1.7 0.7 mm, p < 0.001) were found when comparing L-PRF to open flap debridement (OFD) in IBDs. For furcation defects, significant PD reduction (1.9 1.5 mm, p = 0.01), CAL gain (1.3 0.4 mm, p < 0.001) and bone fill (1.5 0.3 mm, p < 0.001)were reported when comparing L-PRF to OFD. When LPRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 0.3 mm, p > 0.05), CAL gain (0.2 0.5 mm, p > 0.05), KTW (0.3 0.4 mm, p > 0.05) and recession reduction (0.2 0.3 mm, p > 0.05). Conclusions: L-PRF enhances periodontal wound healing.